Unlike most human-grade medications, veterinarians usually give the green light to Benadryl for treating your dog’s anxiety.

Benadryl is not approved for use in dogs by the FDA, but regardless, a majority of vets attest to the safety and effectiveness of Benadryl’s active ingredient for dealing with a variety of symptoms. These include pain, allergic reactions, nausea, and most importantly, anxiety.

Here’s a post on the what, how, when, and why of Benadryl for dogs!

What is Benadryl?

The active ingredient in Benadryl is diphenhydramine, which is an antihistamine. While there are many methods to calm an anxious dog, antihistamines are histamine inhibitors—this means that they work to reduce or block histamines as they are released. The most common triggers of histamines include stress events, phobia, infections, or on contact with allergens.

In dogs, antihistamines such as diphenhydramine have much the same effect as they do in humans. They’re effective at reducing the symptoms of allergies and inflammation, but those same effects can also be applied to improve mental wellbeing. So whether that means reducing symptoms of nausea, unease, or anxiety, antihistamines are often useful for improving a dog’s (or your own) daily wellbeing. This is why diphenhydramine and other antihistamines are so often found in branded medications—from anti-sickness pills to sleep aids!

When would owners use Benadryl for dogs?

There’s many possible reasons why your dog may develop anxiety, with anxiety being one of the main reasons to give a dog Benadryl. It’s always important to seek a prescription (or at least confirmation) from a veterinarian before giving medication to your dog. But assuming you’ve got the OK from a vet, owners normally use Benadryl in three situations:

Using Benadryl for dog anxiety is a great general treatment and a good first port of call, as diphenhydramine will tackle several possible root causes of stress. This means that, whether your dog is anxious due to irritation, phobia, or inflammation, Benadryl should help.

It should be pointed out that Benadryl is a therapeutic treatment for anxiety, not a cure. So in the long term, it’s best to use Benadryl as one part of a wider program to ease your pet’s nervousness. And when it comes to helping your dog ingest Benadryl, many people find that hiding the medication in food—or a specifically designed treat capsule—is the most effective method of delivery.

How much Benadryl should I give my dog?

As a general guide, you should be giving your dog one milligram of Benadryl for every pound of their body weight. This dosage can be given up to three times per day, spaced maximally apart. (So, that means every eight hours for three times per day, every twelve hours for twice per day).

Obviously, the smaller your dog, the more important it is for owners to be exact in their measurements. But dogs of all sizes need to have their medication prepared as accurately as possible. As a quick guide, here’s a dosage chart from Veterinary Place’s article on Benadryl For Dogs: Dosage, Side Effects and More.

Source: Veterinary Place

When trying out Benadryl with your dog for the first time, make sure to keep dosage regular, and expect to keep supplying your pup with medication for around a week or so before seeing any results. Like many medications, antihistamines function best when given a chance to build a baseload, so while some dogs do respond immediately to Benadryl, don’t worry if the effects aren’t instant with your guy.

Are there any risks of side effects of Benadryl use in dogs?

Like all medications, antihistamines are not 100% safe, and it is possible for dogs to overdose. Extra care should be taken with dogs who have a history of seizures, who are pregnant, or who have an underlying health condition. Basically, bear in mind anything a human might need to consider when taking a medication for the first time.

Benadryl has been a mainstay in the treatment of dog anxiety for many years—so, as long as used as prescribed—owners can feel relatively confident that their pup is safe and sound. Side effects with Benadryl tend to be minimal, with the most common effect being drowsiness (which is a part of Benadryl’s calming power).

That said, be sure to read the ingredients label of any medication carefully, before giving it to your dog. Some antihistamine formulas contain non-active ingredients that can be toxic to your pet. For example, liquid medicines often add flavor enhancers such as xylitol, which can be poisonous to some dogs. If you’re going to opt for a liquid antihistamine, Benadryl’s children’s formula is likely the safest (though it still pays to check your specific bottle).

Why would I consider using Benadryl on my dog over other alternatives?

If you’re at all hesitant about treating your dog’s anxiety with a medication designed for humans, Benadryl is undoubtedly the most widely accepted and tried-and-tested option. It’s very likely that your vet has prescribed it at some point to reduce anxiety in pets for traveling, storms, phobia, etc.

But Benadryl isn’t the only option when it comes to anti-anxiety treatments for your dog. Newer antihistamines on the market, such as Zyrtec, and even CBD oil to combat anxiety in dogs can provide more powerful effects with the proper dosage. This can be useful for larger dogs, who when using Benadryl, are likely to require multiple doses, several times per day.

If you’re looking into CBD as an anxiety treatment beyond Benadryl, check out out best CBD oil for dogs that reviews both products on the market and general information around CBD & canines. Both types of oil replicate the effects of pharmaceutical pain and anxiety relievers, without the risk of toxicity—so they’re well worth discussing with your veterinarian.