Despite improvements in animal healthcare, rates of canine cancer have never been higher. With most dogs now making it to a wise old age, cancer is often an inevitable part of senior life for pups.

Thankfully, CBD is providing a growing number of owners with a tool to relieve cancer symptoms, and in some cases, directly slow the progression of disease.

What makes a CBD oil right for canine cancer?

CBD’s potential as a cancer treatment comes from its ability to stimulate receptors in the endocannabinoid system (ECS).

Found in dogs and humans, the ECS controls inflammation across the body, as well as the release of key hormones and other signaling compounds. In 2011, a review from the British Journal of Pharmacology on cancer and the endocannabinoid system found that:

“The available literature suggests that the endocannabinoid system may be targeted to suppress the evolution and progression of breast, prostate, and bone cancer as well as the accompanying pain syndromes.”

A large number of clinical studies confirm that CBD and other cannabis compounds can target the ECS in exactly this way. Among these compounds, two have drawn particular attention from researchers.

In trials by U.S. company Cannabics Pharmaceuticals, CBC and CBG showed anti-tumor properties. They were able to penetrate tumor cells and initiate necrosis (tissue death) to a greater extent than other cannabinoids.

Similar clinical studies have shown that CBG inhibits the growth of grafted tumors and chemically induced colon cancer.

Top choice – Charlotte’s Web Full Spectrum Hemp Extract Drops

Top Choice
Charlotte’s Web – Full Spectrum Hemp Extract Drops

Runner up – 4 Corners Cannabis Pet Tincture

Runner up
4 Corners Cannabis Pet Tincture
Best value
Receptra Naturals Pet Tincture

Because of this, all the CBD products on this page contain significant amounts of both CBC and CBG.

We also take into account our overall scoring categories, which combine the features owners care about most, weighted by importance.

These include things like product label accuracy, THC safety, and previous customer reviews.

For the full details on our selection process, take a look at how we calculate our CBD scores.

Best CBD Oil for Dogs with Cancer in 2022

Top choice

  • Label Accuracy
    100% accurate

  • Cannabinoids
    7/7 beneficial cannabinoids

  • Carrier Oil
    MCT/Coconut oil

  • Owner Reviews
    Minimal independent reviews

  • Shopping experience
    Free shipping on orders over $74
    Subscribe and save 10%

  • Safe THC
    Safe for dogs

Charlotte’s Web CBD oil for dogs offers true full-spectrum extraction, containing all seven of the main cannabinoids we look for.

The brand earns our top choice for CBD oils for cancer with high amounts of CBG and CBC, as well as the usual pain and inflammation-busting benefits that come with any quality CBD extract.

This makes Charlotte’s Web a good option for owners looking to target symptoms of cancer as well as the underlying disease. Owners of senior dogs and those taking CBD as part of their end-of-life care should benefit from additional compounds like CBD-A, and CBN, which work with CBD to target inflamed tissues and joints.

A look at Charlotte’s Web owner reviews shows that many were impressed with the oil’s ability to support dogs with pain, joint and mobility issues, and pain-related depression.

They also ranked in our overall best CBD oil for dogs.

Runner up


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  • Label Accuracy
    93.1% Accurate

  • Cannabinoids
    4/7 beneficial cannabinoids

  • Carrier Oil
    Hemp Seed Oil

  • Owner Reviews
    4.8/5 stars from 660 reviews

  • Shopping experience
    Free shipping on orders over $100

  • Safe THC
    Safe for dogs

Multiple award-winners Four Corners Cannabis are a solid choice for any pup, but they stand out for dogs with cancer thanks to super-high levels of CBD and CBG—among the highest of any pet CBD oil on the market today.

As one of a small minority of cannabis brands to be promoted by the American Veterinary Association, Four Corners also has a great online reputation.

Owners posting on Trustpilot US give this brand’s CBD range an excellent 4.8 out of 5, from 677 reviews. Even more promisingly, there are clear indications that Four Corners works well for senior dogs, dogs with joint problems, and those with cancer, especially osteosarcoma.

What are customers saying?

4.9/5.0 7012 reviews

David H.
“I am treating my German Shepherd dog for bone cancer. Along with many other things, this CBD seems to be helping.”

“I get the 2000 mg for my 11 yr Golden Retriever Jack. He has (hopefully had) cancer on his spine. The CBD tincture seems to help his pain. 2000 mg bottle is an incredible value”

“Great pricing for a high-quality product. Has really helped keep our pup with bone cancer more comfortable.”

Four Corner’s extract is made from premium colorado hemp, which includes high amounts of CBC and CBG along with CBD.

The extraction is carried in organic golden hemp oil, which is our favorite type of carrier oil thanks to hemp’s optimal ratio of omega 3 and 6 fatty acids. Using a high-quality fatty oil to deliver CBD increases the amount of extract absorbed into dogs’ bodies.

Despite all this good news, Four Corners is our runner-up pick due to their labeling accuracy, which is a little behind other brands.

We found that real levels of CBD inside the bottle could vary by up to 10 percent above or below the amount stated on the label. While this isn’t a huge issue, it can make products a little more difficult to dose.

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Best value

  • Label Accuracy
    95.2% Accurate

  • Cannabinoids
    5/7 beneficial cannabinoids

  • Carrier Oil
    Organic MCT/Coconut oil

  • Owner Reviews
    4.8/5 stars from 206 reviews

  • Shopping experience
    30 day money-back guarantee
    Free shipping on all orders

  • Safe THC
    Safe for dogs

We think this CBD oil for dogs from Receptra Naturals achieves an awesome balance of ingredient quality and value for money. That said, the extract contains about half the CBC and CBG of Four Corners and Charlotte’s Web, so there is a sacrifice in potency that comes with the reduced price tag.

Levels of CBD, CBC, and CBG are still impressive, however, for a cost per mg of CBD that’s about half the industry average.

If you’re looking for a budget CBD oil that has particular relevance for canine cancers, we think this is the best option out there.

CBD and cancer

Combination treatment

Just like cancer in humans, no two cases of cancer are the same, and dogs may need different combinations of treatment, including surgery, chemotherapy, radiation, and immunotherapy.

Likewise, dogs with cancer will use CBD in different ways—some responding so well that it becomes part of their primary treatment, while others use supplementation to offset symptoms and the side effects of other medications.

Owners and vets should work together to find the treatment plan that most benefits their dog, but evidence in favor of CBD’s role amongst pre-existing therapies is steadily growing.

A 2018 study found that giving CBD to mice undergoing radiation therapy resulted in a great reduction in cancer cells than in mice using radiation therapy alone. A similar study found that mice treated using CBD in combination with a chemotherapy drug lived almost three times longer than the control group.

In the future, this kind of clinical evidence may allow veterinary oncologists to reduce the amount of radiation used on dogs with cancer, instead prescribing courses of CBD and other cannabis compounds.

Tumor reduction

No one should be touting CBD as a cure for cancer, and recent discoveries about cannabis compounds don’t replace the need for traditional treatment options.

But there are a growing number of anecdotal reports from owners who were seemingly able to directly affect their dog’s cancer prognosis through CBD supplementation.

In human and mice models of cancer, CBD and other cannabis compounds (primarily CBG and CBC) have been directly associated with cancer cell reduction. Researchers believe that CBD may protect DNA inside cells from oxidative stress, a primary cause of age-related cancer and a possible route to slowing cancer progression.

CBD is minimizing reliance on drugs

Above all, CBD is an anti-inflammatory supplement, which means that it can be used to soothe a large variety of pains and discomforts.

Specifically, CBD can help dogs cut down on their usage of NSAID and opioid pain management medications, which cause unwanted side effects in many pups.

  • Non-steroidal anti-inflammatory drugs (NSAIDs) may cause gastrointestinal distress and decreased activity levels. CBD stimulates the ECS into a natural anti-inflammatory response.
  • Opioids can cause lethargy, fast tolerance formation, and potential overdose. While CBD can’t compete with the pain-relieving power of opioid drugs, it helps remove discomfort and doesn’t create dependency, even over long-term use.

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